Piezo-herbal microneedle patches enable wireless endometrial regeneration and fertility recovery - PubMed
4 hours ago
- #Endometrial Regeneration
- #Ultrasound Therapy
- #Microneedle Patch
- Developed an ultrasound-responsive microneedle patch for endometrial repair using curcumin and piezoelectric KNN nanoparticles.
- Patch enables controlled drug release, antioxidant activity, and piezoelectric stimulation under ultrasound.
- In vitro tests showed biocompatibility, ROS scavenging, anti-inflammatory, and pro-angiogenic effects.
- In rat model, ultrasound activation promoted microcurrent generation and enhanced regeneration of endometrium.
- Treatment improved endometrial thickness, reduced fibrosis, and restored fertility with higher embryo implantation rates.
- System offers a minimally invasive strategy for in situ tissue regeneration and functional recovery.