Yi Qi Cong Ming Decoction control the progression of lens-induced myopia in rats by modulating the cAMP/PKA/HIF-1α pathway - PubMed
3 hours ago
- #traditional Chinese medicine
- #cAMP/PKA/HIF-1α pathway
- #myopia
- Yi Qi Cong Ming Decoction (YQCM) controls lens-induced myopia (LIM) progression in rats by modulating the cAMP/PKA/HIF-1α pathway.
- YQCM significantly reduces axial elongation by 30.3% in prevention and 25.8% in treatment groups.
- YQCM alleviates scleral thinning and promotes regular collagen fiber arrangement.
- Mechanistically, YQCM downregulates cAMP, PKA, and HIF-1α while upregulating TGF-β1 and bFGF.
- YQCM inhibits scleral extracellular matrix degradation and promotes collagen synthesis.
- The study suggests YQCM as a multi-targeted therapeutic strategy for myopia control.