Dorsal root ganglion macrophages mediate osteoarthritis pain via disruption of sensory neuron perineuronal nets - PubMed
3 hours ago
- #Osteoarthritis Pain
- #Macrophages
- #Perineuronal Nets
- Osteoarthritis (OA) pain involves dorsal root ganglion (DRG) macrophages disrupting perineuronal nets (PNNs) around sensory neurons.
- In an OA model, PNN disruption correlated with pain symptoms like mechanical allodynia and thermal hyperalgesia.
- Experimentally disrupting PNNs worsened pain and increased C-fiber activity, while protecting PNNs alleviated pain.
- Macrophages were activated via the IL-33/ST2 signaling pathway, contributing to PNN degradation.
- Targeting the IL-33/ST2 axis in macrophages preserved PNNs, reduced activation, and relieved OA pain, suggesting a therapeutic target.