STING-NF-κB signaling builds an influenza spillover barrier - PubMed
3 hours ago
- #Influenza
- #Zoonotic
- #STING-NF-κB
- Human STING acts as a transmission barrier against avian influenza A viruses (IAVs).
- STING activates NF-κB and downstream genes, with GADD34 playing a crucial role in IAV restriction.
- Some IAVs evade human STING by mutating residue 115 in their M1 protein.
- This mechanism provides insight into zoonotic threats and the cGAS-STING-NF-κB signaling pathway.