Comparative Effectiveness of Antihypertensive Medications in Children With Chronic Kidney Disease - PubMed
4 hours ago
- #chronic kidney disease
- #pediatrics
- #antihypertensive medications
- Hypertension is a major modifiable factor for kidney function decline in chronic kidney disease (CKD).
- Comparative trials of antihypertensive medications in pediatric CKD are lacking.
- The study evaluated the comparative effectiveness of RAASi vs CCB in preserving kidney function in children with CKD.
- The study used target trial emulation methods with data from the PRESERVE study, including 2762 children and adolescents.
- RAASi was associated with reduced risk of kidney replacement therapy and better blood pressure control compared to CCB.
- The findings support first-line use of RAASi for antihypertensive treatment in pediatric CKD.