E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies - PubMed
4 hours ago
- #therapeutic strategies
- #E3 ubiquitin ligases
- #targeted protein degradation
- E3 ubiquitin ligases are central to the Ubiquitin-Proteasome System (UPS), directing protein ubiquitination for degradation.
- Main families include RING, HECT, RBR, RCR, and non-canonical ligases, involved in processes like proteostasis, DNA repair, and cell-cycle control.
- Dysregulation of E3 ligases contributes to diseases such as cancers, neurodegenerative diseases, and immune dysfunctions.
- Emerging therapeutic strategies focus on E3 ligases, including PROTACs and modulatory approaches to enhance CAR-T-cell immunotherapies.
- AI and machine learning are transforming research by enabling high-throughput screening and rational design of degraders.