HTRA1+ macrophages induce T cells egress through CRIP1/NF-κB/CXCL12 to limit the effects of immunotherapy in triple-negative breast cancer - PubMed
2 hours ago
- #immunotherapy
- #TNBC
- #macrophages
- HTRA1+ macrophages limit immunotherapy efficacy in triple-negative breast cancer (TNBC).
- These macrophages induce T cell egress via the CRIP1/NF-κB/CXCL12 pathway.
- Loss of HTRA1 in macrophages delays TNBC growth and increases CD8+ T cell infiltration.
- Endothelial cell-derived CX3CL1 recruits HTRA1+ macrophages to tumor sites.
- Pharmacological inhibition of CXCL12/CXCR4 enhances immunotherapy efficacy in TNBC models.