Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia - PubMed
5 hours ago
- #cognitive health
- #dementia
- #AQP4
- The study investigates the association of an AQP4 haplotype with cognition, brain volume, and dementia risk in individuals without dementia.
- Participants from the Framingham Heart Study and UK Biobank were analyzed for cognitive testing, brain MRI outcomes, and incident dementia.
- Heterozygotes showed better verbal episodic memory and larger hippocampal volumes compared to homozygote majors.
- In the UK Biobank, homozygote minors had larger hippocampal volumes and lower free water levels.
- Heterozygotes also exhibited a lower rate of incident all-cause dementia compared to homozygote majors.
- Carrying at least one minor allele at the AQP4 haplotype was linked to better memory, larger hippocampal volumes, and reduced dementia risk.