CD49d governs immune synapse formation through actin rearrangements and synchronizes BCR signaling in CLL - PubMed
4 days ago
- #CLL
- #BCR signaling
- #CD49d
- CD49d is crucial for immune synapse formation via actin rearrangements in CLL.
- CD49d influences bone marrow infiltration patterns and patient outcomes in CLL.
- CD49d-deficient cells show impaired immune synapse formation and actin remodeling.
- Transcriptome analyses reveal CD49d-dependent regulation of actin-associated pathways.
- CD49d synchronizes BCR-related downstream signaling, including Syk and PLCγ activation.
- CD49d and BCR signaling converge on a focal adhesion kinase-actin axis.