Extracellular payload release from non-internalizing antibody-drug conjugates: mechanisms and linker technologies - PubMed
4 hours ago
- #linker technologies
- #bystander effect
- #Antibody-drug conjugates
- Antibody-drug conjugates (ADCs) play a significant role in precision oncology by delivering cytotoxic drugs directly to cancer cells.
- Traditional ADCs rely on endocytosis and intracellular payload release, but face challenges like antigen loss and tumor heterogeneity.
- Noninternalizing ADCs use extracellular payload release methods to overcome these challenges.
- Advanced linker technologies ensure stability in vivo and selective activation in the tumor microenvironment.
- The 'bystander effect' allows effective cytotoxic diffusion among tumor cells.
- The review covers the evolution of linker designs, categories of noninternalizing ADC linkers, and recent clinical developments.
- Focuses on enhancing the efficacy and safety of ADCs in oncology applications.