TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β-Catenin Signalling Pathway in Obstructive Nephropathy - PubMed
4 days ago
- #TREM2
- #macrophage polarization
- #renal fibrosis
- TREM2 in macrophages promotes renal fibrosis via β-catenin signaling in obstructive nephropathy.
- TREM2 expression is elevated in human fibrotic kidneys and co-localizes with macrophages.
- Unilateral ureteral obstruction (UUO) in mice increases TREM2, M2 macrophage polarization, and fibrosis.
- Trem2 deficiency (Trem2-/-) reduces fibrosis, M2 polarization, and preserves GFR in UUO mice.
- TREM2 inhibitory peptide IA9 decreases fibrosis and M2 polarization in UUO mice.
- Trem2-/- bone marrow-derived macrophages (BMDMs) show reduced M2 polarization, migration, and β-catenin expression.
- Lithium chloride (LiCl) rescues β-catenin-related impairments in Trem2-/- BMDMs.
- TREM2 blockade is a potential therapeutic strategy for obstructive nephropathy.