Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects - PubMed
5 hours ago
- #urinary microbiome
- #non-infectious urological diseases
- #metagenomic sequencing
- The traditional concept of sterile urine has been overturned due to advancements in 16S rRNA sequencing and metagenomic technologies.
- Dysbiosis of the urinary microbiome is linked to non-infectious urological diseases like bladder cancer, prostate cancer, and interstitial cystitis.
- Alterations in the urinary microbiome contribute to disease through chronic inflammation, immune dysregulation, and metabolic disturbances.
- Non-invasive urinary microbial profiling shows promise for early diagnosis of bladder and prostate cancers, with some models achieving over 80% accuracy.
- The urinary microbiome may influence immunotherapy efficacy, offering potential for personalized medicine.
- Standardization of research methods is crucial for advancing clinical applications of urinary microbiome studies.