A Case for Anti-IgE Vaccination - PubMed
7 hours ago
- #IgE
- #vaccination
- #allergy
- IgE plays a central role in allergic diseases by binding to FcεRI on mast cells and basophils, triggering inflammatory responses.
- Monoclonal anti-IgE therapy with omalizumab is effective but limited by high cost and the need for repeated dosing.
- Vaccination against IgE offers a cost-effective alternative, with recent research showing it can neutralize free IgE without activating effector cells.
- Natural anti-IgE autoantibodies may regulate IgE homeostasis, supporting the safety and biological grounding of anti-IgE vaccination.
- Anti-IgE vaccination is a promising strategy for long-term control of IgE-mediated allergic diseases.