TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy - PubMed
12 hours ago
- #neuropathic pain
- #TRPM3
- #trigeminal neuron
- TRPM3 plays a crucial role in mediating spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy.
- Wild-type mice develop chronic pain symptoms after infraorbital nerve injury, while Trpm3-/- mice do not.
- Longitudinal RNA-seq analysis shows similar transcriptome changes in trigeminal ganglia of both WT and Trpm3-/- mice, suggesting TRPM3's role is not at the transcriptional level.
- TRPM3 antagonists (primidone and isosakuranetin) effectively reverse pain symptoms, whereas TRPV1 antagonist (mavatrep) does not.
- TRPM3 is identified as a potential therapeutic target for trigeminally mediated neuropathic pain.