Stability-centric Development of mRNA Vaccines: A Comprehensive Review of Design, Delivery, and Regulatory Considerations - PubMed
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- #vaccine technology
- #mRNA vaccines
- mRNA vaccine technology is a revolutionary platform in immunology and vaccinology.
- mRNA vaccines deliver genetic instructions to host cells to produce antigenic proteins.
- Challenges include mRNA instability, degradation by RNases, and delivery barriers.
- Review focuses on mRNA stabilization, delivery systems, immunogenicity, and clinical applications.
- Formulation strategies include nucleoside-modified mRNA, self-amplifying mRNA, and circular mRNA.
- Delivery vectors like lipid nanoparticles (LNPs) protect mRNA and enable targeted delivery.
- mRNA vaccines show potential in cancer immunotherapy and personalized medicine.
- Clinical findings confirm high efficacy but note reactogenicity and cold-chain limitations.
- Ongoing research aims to improve thermostability and reduce adverse immune responses.
- Advances in delivery systems and regulatory frameworks are essential for broader application.