HBx Promotes Liver Cancer Cells to Escape NK-92 Cell Attack by Mediating ADAM10 to Enzyme Cut MICA/B Shedding From Cancer Cell Membrane - PubMed
4 days ago
- #Immune Evasion
- #HBV
- #Hepatocellular Carcinoma
- HBx promotes MICA/B shedding from liver cancer cell membranes, aiding escape from NK-92 cell attacks.
- HBx upregulates ADAM10 activity, which cuts MICA/B from HCC cell surfaces, reducing immune detection.
- High expression of HBx, MICA/B, and HIF-1α observed in HBV-infected HCC tissues.
- Inhibitors LW-6 (HIF-1α) and GI254023X (ADAM10) reverse HBx effects, restoring MICA/B membrane levels.
- HBx overexpression increases HCC resistance to NK-92 cells and reduces cytokine secretion (IFN-γ, IL-2, IL-10).
- HBx activates HIF-1α pathway to regulate ADAM10, facilitating immune evasion in HCC.