Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress - PubMed
3 days ago
- #SCD1
- #radioprotection
- #gut microbiota
- Tyrosol, a gut-derived metabolite, alleviates radiation-induced intestinal injury (RIII).
- Tyrosol targets stearoyl-CoA desaturase 1 (SCD1), boosting its activity and increasing monounsaturated fatty acids (MUFAs).
- Increased MUFAs inhibit ER stress via the p-eIF2α/ATF4/CHOP axis, reducing radiation-induced cytotoxicity.
- SCD1 inhibition abolishes tyrosol's protective effects, confirming its essential role in radioprotection.
- MUFA supplementation restores tyrosol's radioprotective effects in SCD1-deficient cells.
- The study highlights SCD1 activation as a promising therapeutic strategy against gastrointestinal radiation injury.