Migraine induced by vascular KATP channel activation is independent of HCN channel activity: A randomised controlled trial with translational validation - PubMed
4 hours ago
- #Migraine
- #HCN channel
- #KATP channel
- A randomized controlled trial showed that HCN channel blockade with ivabradine does not reduce migraine incidence induced by vascular KATP channel activation via levcromakalim.
- Both human and preclinical mouse model results were consistent, indicating HCN channels are not essential for migraine pain from vascular KATP channel signaling.
- The study supports a model where migraine initiation involves signaling at the vessel-to-neuron interface, independent of HCN channel activity.