Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies - PubMed
4 hours ago
- #androgenetic alopecia
- #hair loss
- #pharmacogenetics
- Male pattern hair loss (androgenetic alopecia) is a prevalent condition with significant psychosocial impact, but current therapies show variable efficacy.
- Genetic studies have identified susceptibility loci related to androgen signaling, WNT pathways, prostaglandin metabolism, and other biological processes.
- Pharmacogenetic research links genetic variants to differences in treatment response to minoxidil, finasteride, dutasteride, and prostaglandin-based therapies.
- Emerging therapeutic targets include IGF1R, WNT10A, PPARGC1A, and prolactin receptor signaling.
- Future approaches may involve RNA-based androgen receptor silencing and stem-cell-derived regenerative strategies.
- The review advocates for genetically informed, mechanism-based treatment algorithms incorporating pharmacogenetic markers and polygenic scores.