Inflammatory markers associated with albuminuria and early atherosclerosis in type 2 diabetic kidney disease: a cross-sectional study - PubMed
4 hours ago
- #inflammation
- #diabetic kidney disease
- #atherosclerosis
- Albuminuria is a marker of renal injury in diabetic kidney disease (DKD) and may drive systemic inflammation and atherosclerosis.
- A cross-sectional study of 362 type 2 diabetes patients with moderate CKD evaluated associations between albuminuria, inflammatory markers, and subclinical atherosclerosis (SA).
- SA was present in 46% of patients, with albuminuria (UACR) correlating with carotid intima-media thickness (CIMT) and ankle-brachial index (ABI).
- Higher UACR was linked to increased circulating IL6 and IL1β, and elevated leukocyte expression of TNF, CD36, and TLR2.
- Multivariable analysis identified serum IL6, IL1β, and leukocyte IL6 and TLR2 as independently associated with SA.
- Mediation analysis suggested IL6, IL1β, and TLR2 partially mediate the association between albuminuria and SA.
- Inflammatory pathways may partly explain the link between albuminuria and early atherosclerosis, though findings require cautious interpretation due to the cross-sectional design.