Telomeric repeat-containing RNA G-quadruplexes trigger ZBP1-mediated cell death - PubMed
4 hours ago
- #cell death
- #ZBP1
- #G-quadruplex
- ZBP1-S senses telomeric repeat-containing RNA (TERRA) and triggers inflammatory cell death.
- G-quadruplexes (G4s) in TERRA are directly sensed by ZBP1-S, leading to oligomerization and cell death.
- G4-specific binding ligands can inhibit ZBP1-S activation by competing for TERRA G4 binding.
- The study reveals a new mechanism linking TERRA G4s to ZBP1-S-mediated inflammatory cell death.