Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans - PubMed
4 hours ago
- #C. elegans
- #epigenetics
- #RNA interference
- Epigenetic inheritance, mediated by small RNAs, varies in duration across generations in C. elegans wild strains.
- Some wild strains show no memory of gene silencing, while others exhibit longer memory than the reference strain.
- Natural DNA sequence polymorphisms, such as in the set-24 gene, influence the duration of small RNA inheritance.
- Silencing memory duration increases with temperature and is retained during early starvation arrest and dauer diapause.
- The study highlights intraspecific diversity in small RNA-based heredity, suggesting potential for evolutionary selection.