Ergothioneine prevents ovariectomy-induced osteoporosis by suppressing NF-κB/p65 signalling to attenuate osteoclastogenesis and bone marrow inflammation - PubMed
4 hours ago
- #osteoporosis
- #ergothioneine
- #NF-κB signaling
- Ergothioneine (EGT) prevents osteoporosis by suppressing NF-κB/p65 signaling.
- EGT reduces osteoclastogenesis and bone marrow inflammation in ovariectomy-induced osteoporosis.
- The study used an oestrogen-deficient mouse model to evaluate EGT's preventive effects.
- EGT administration preserved bone microstructure and mitigated bone loss.
- Mechanistically, EGT inhibits mitochondrial ROS, p65 phosphorylation, and NF-κB/NFATc1 signaling.
- EGT systemically remodels the bone marrow microenvironment to be anti-inflammatory.
- The findings highlight EGT's potential as an early preventive strategy for osteoporosis.