Mechanoresilience of lysosomes conferred by TMEM63A - PubMed
a day ago
- #lysosomes
- #TMEM63A
- #mechanoresilience
- Lysosomes can experience membrane tension due to osmotic shifts, toxins, or luminal growth.
- TMEM63A, a lysosome-resident cation channel, helps relieve membrane tension by allowing monovalent cations to exit the lysosome.
- This mechanism helps lysosomes regulate hydrostatic pressure and volume, preventing rupture.
- Lysosomes lacking TMEM63A or with disease-causing variants are more prone to lysis under tension.
- The study highlights TMEM63A's role in lysosomal mechanoresilience.