RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production - PubMed

4 hours ago

RIPK3 activation triggers MLKL phosphorylation, caspase activation, and gasdermin cleavage, leading to PANoptosis.
Sequential recruitment of MLKL and RIPK1 to RIPK3 aggregates occurs based on differential affinities for RIPK3 oligomeric states.
Cross-regulation between pathways modifies cellular morphology, DAMPs release, and chemokine secretion, distinct from classical cell death pathways.
The RIPK3 complex acts as a platform to integrate different programmed cell death pathways, offering a target for inflammatory diseases.

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