Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells - PubMed
a day ago
- #thymus
- #T cell maturation
- #spatial transcriptomics
- Spatial cartography of human thymus reveals distinct architectural features.
- Study uses Stereo-seq spatial transcriptomics to map human fetal and pediatric thymi.
- Thymus regions include outer cortex, inner medulla, and septa with various cell types.
- Identifies lineage-defining transcription factors (TFs) regulating rare mimetic thymic epithelial cells (TEC).
- Provides a high-resolution spatial atlas for further research on thymus development and function.