Purine salvage pathway protects CD8+ T cells from metabolic stress - PubMed
5 hours ago
- #CD8+ T cells
- #metabolic stress
- #purine salvage pathway
- High-fat diet exposure impairs antitumor immunity in CD8+ T cells even after returning to a normal diet, due to lasting metabolome changes.
- Metabolic stress leads to increased phospholipid peroxidation and reduced antioxidants, making CD8+ T cells vulnerable to ferroptosis.
- CD8+ T cells use the xanthine salvage pathway to produce GTP and increase tetrahydrobiopterin, mitigating oxidative stress.
- Supplementing with xanthine reduces lipid peroxidation and improves antitumor immunity in mice previously on a high-fat diet.