SET1B Drives Sustained HIF activity and Disease Progression in Clear Cell Renal Cell Carcinoma - PubMed
4 hours ago
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- #HIF
- SET1B, a histone H3 lysine 4 methyltransferase, coordinates sustained HIF-mediated transcriptional activity by interacting with RNA polymerase II.
- In clear cell renal cell carcinoma (ccRCC), SET1B is critical for sustained HIF activity and correlates with disease progression and metastasis.
- Depletion of SET1B enhances the efficacy of HIF-2 inhibitors, suggesting it as a potential therapeutic target in ccRCC.