The bidirectional effects and mechanisms of the oral and gut microbiomes: a narrative review - PubMed
a day ago
- #microbiome
- #systemic health
- #dysbiosis
- The gut and oral microbiota are the two largest microbial communities in the human body, containing thousands of bacteria, fungi, and viruses.
- Under normal conditions, these microbiotas maintain homeostasis and protect against pathogenic colonization.
- Pathogens like Porphyromonas gingivalis can translocate from the oral cavity to the gut, disrupting gut microbial homeostasis and increasing disease risk.
- Mechanisms of interaction include new symbiotic relationships, intestinal barrier disruption, immune cell balance (Th17/Tregs), and systemic inflammation.
- Gut microbiota dysbiosis (e.g., in IBD, IBS, or colorectal cancer) is linked to changes in oral microbiota composition and diversity.
- Factors like immune cell migration, malnutrition, and taste disturbances may contribute to oral microbial imbalance.
- Understanding these bidirectional interactions can improve knowledge of microbiota-host relationships and systemic disease prevention/treatment.