Two Costimulations Are Better Than One: Role of Endogenous CD28 in 4-1BB CAR T Cells - PubMed
3 hours ago
- #CD28
- #4-1BB
- #CAR T cells
- Endogenous CD28 signaling enhances 4-1BB CAR T-cell function.
- CD28 promotes metabolic fitness, proliferation, and sustained antitumor activity in CAR T cells.
- Cooperative signaling between CD28 and 4-1BB improves CAR T-cell potency and persistence.
- Findings suggest dual costimulation enhances therapeutic efficacy of CAR T cells.