Immunogenetic variants in major mental and neurodevelopmental disorders - PubMed
19 hours ago
- #Mental Disorders
- #Neurodevelopment
- #Immunogenetics
- Immunogenetic variants are linked to major mental and neurodevelopmental disorders, including bipolar disorder, recurrent depression, schizophrenia, autism spectrum disorders, and ADHD.
- Abnormal immune processes may cause chronic low-grade inflammation in some patients, leading to poor prognosis, treatment resistance, and functional decline.
- Interactions between immunogenetic factors and environmental risks (e.g., infections, pollution, stress) contribute to inflammation, emphasizing the need to understand immune genes and mechanisms for better patient stratification and treatment.
- Both innate and adaptive immunity genes play a role, with the Psychiatric Genomics Consortium identifying MHC-region associations in schizophrenia and bipolar disorders.
- Research aims to bridge gaps in knowledge to develop personalized therapeutic strategies based on immunogenetic information in immuno-psychiatry.