The gut-brain connection: microbes' influence on mental health and psychological disorders - PubMed
5 hours ago
- #gut-brain axis
- #microbiome
- #mental health
- The gut microbiome plays a crucial role in brain function and mental health through the gut-brain axis.
- Microbial communities affect neurodevelopment, neurotransmission, and behavior via pathways like the vagus nerve, immune signaling, and metabolites.
- Dysbiosis is linked to psychiatric conditions such as depression, anxiety, schizophrenia, autism spectrum disorder, and bipolar disorder.
- Potential microbiome-targeted interventions include probiotics, fecal microbiota transplantation (FMT), and dietary modulation.
- Current limitations include correlational studies, small sample sizes, and lack of standardized methodologies.
- Future research should focus on large-scale clinical trials to validate findings and develop personalized microbiome-based therapeutics.