Is Low-Dose Aspirin the Safest Prophylaxis for Venous Thromboembolism Following Primary Total Hip Arthroplasty? - PubMed
4 hours ago
- #VTE Prophylaxis
- #Total Hip Arthroplasty
- #Aspirin
- Low-dose aspirin (LDA) monotherapy is endorsed by the 2022 International Consensus Meeting (ICM) as the preferred VTE prophylactic agent for hip and knee arthroplasty patients.
- A study of 141,334 primary THA patients (2012-2025) compared LDA monotherapy with other anticoagulants, stratified by high- and low-risk VTE cohorts.
- LDA monotherapy showed significantly lower odds of DVT and PE compared to other anticoagulants in both high-risk and low-risk patients.
- LDA-only regimens also demonstrated reduced rates of hemorrhages, infections, transfusions, readmissions, emergency department visits, and mortalities.
- Combination prophylaxis (LDA plus another anticoagulant) was associated with increased VTE risk and complication rates compared to LDA alone.
- Rivaroxaban monotherapy showed no significant differences in outcomes when compared with LDA.
- The findings support the 2022 ICM-VTE recommendations, endorsing LDA as a safe and effective prophylactic option across THA patient risk profiles.