Targeting the Keap1-Nrf2/GPX4 axis to suppress ferroptosis in acute lung injury - PubMed
3 hours ago
- #Keap1-Nrf2
- #Acute lung injury
- #Ferroptosis
- Acute lung injury (ALI) is a severe condition with high mortality and limited treatment options.
- Kaempferol-3-O-α-L-(4″-E-p-coumaroyl)-rhamnoside (KAE) from Angelica acutiloba Kitagawa flowers reduces inflammation and oxidative stress in ALI.
- KAE binds to Keap1 at Arg415, disrupting Keap1-Nrf2 interaction, promoting Nrf2 nuclear translocation, and activating antioxidant and anti-ferroptosis pathways.
- Mutation at Keap1 Arg415 prevents KAE's therapeutic effects, highlighting its critical role.
- KAE shows promise as a therapeutic agent for ALI by targeting the Keap1-Nrf2/GPX4 axis.