The role of OSM/OSMRβ axis in shaping the tumor microenvironment favouring MASLD-Related HCC immune evasion - PubMed
3 hours ago
- #Tumor Microenvironment
- #Immunosuppression
- #Hepatocellular Carcinoma
- OSM/OSMRβ axis plays a key role in promoting immune evasion in MASLD-related HCC.
- OSM expression correlates with immunosuppressive tumor microenvironment (TIME) markers in HCC patients and murine models.
- Hepatocyte-specific OSM receptor-β (hOSMRβ-/-) deficiency reduces tumor volume and TIME markers in MASH-HCC.
- OSM/OSMRβ axis enhances STAT3 phosphorylation and COX-2 activity, contributing to immunosuppression.
- Malignant hepatocytes produce CCL15, a cytokine linked to immunosuppression, elevated in MASH-HCC.
- Blocking OSM signaling reduces CCL15 production and TIME marker expression in co-cultured macrophages.
- OSM/OSMRβ axis is a potential therapeutic target for HCC treatment.