Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study - PubMed
3 hours ago
- #DLB
- #neuroimaging
- #transcriptomics
- A study used imaging transcriptomics to explore the link between normative gene expression patterns and regional brain atrophy in 164 dementia with Lewy bodies (DLB) patients compared to healthy controls.
- DLB patients exhibited widespread atrophy across most brain regions, with normative expression of genes like MAPT, PINK1, and PSEN2 predicting atrophy in the full cohort, but not surviving multiple-testing correction.
- In a Mayo Clinic sub-cohort, expression of APP, BIN1, GBA, MAPT, PINK1, SNCA, and TMEM175 significantly predicted atrophy and survived multiple-testing correction, with random forest models highlighting PARK7, PINK1, and PSEN2 as important predictors.
- The findings suggest that normative gene expression partially explains regional vulnerability to atrophy in DLB, highlighting genes involved in alpha-synuclein, beta-amyloid, and tau pathology.