GPR75 in glutamatergic neurons regulates body weight - PubMed
9 hours ago
- #obesity
- #GPR75
- #glutamatergic neurons
- GPR75 in glutamatergic neurons plays a key role in regulating body weight and protecting against diet-induced obesity (DIO).
- Loss-of-function mutations in GPR75 are linked to lower BMI in humans, and Gpr75-deficient mice are resistant to DIO.
- Selective deletion of Gpr75 in vGlut2+ glutamatergic neurons (Gpr75vGlut2-KO) prevents high-fat diet (HFD)-induced weight gain, while deletion in GABAergic neurons does not.
- Male Gpr75vGlut2-KO mice exhibit reduced food intake on HFD without changes in energy expenditure.
- Reactivation of Gpr75 specifically in vGlut2-expressing cells (Gpr75TB) fully restores HFD-induced weight gain, whereas reactivation in GABAergic cells has no effect.
- The study highlights the critical role of glutamatergic neurons in GPR75-mediated regulation of food intake and obesity protection.