A renaissance in targeting the PI3K/AKT/mTOR pathway - PubMed
7 hours ago
- #PI3K/AKT/mTOR pathway
- #therapeutic modulation
- #drug development
- The PI3K/AKT/mTOR pathway is a promising drug target for cancer, immune regulation, and genetic disorders due to its druggability.
- Drug development targeting this pathway has faced challenges including tolerability issues and resistance mechanisms.
- New pharmacological approaches and improved biological and clinical understanding are renewing interest in therapeutic modulation of this pathway.