Is Sex by Age Interaction The Missing Factor in Acute Kidney Injury Epidemiology? - PubMed

3 hours ago

Acute kidney injury (AKI) is a multifactorial syndrome linked to increased morbidity and mortality.
The study explores the impact of sex and age on AKI epidemiology and outcomes.
Data from 87,087 adult patients admitted to Italian hospitals (2016-2019) were analyzed.
AKI occurred in 20.6% of patients, with a higher incidence in females (21.4%) than males (19.8%).
Female patients were older, had lower eGFR at admission, and less diabetes but more congestive heart failure.
Stage 3 AKI was more common in males, while undiagnosed stage 1 AKI was more frequent in females.
Age-stratified analysis showed higher AKI incidence in younger males but higher incidence in oldest females.
Older male AKI patients had worse outcomes (mortality, ICU admission, hospital stay).
The study highlights the importance of sex-by-age interaction in AKI epidemiology and outcomes.

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