HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation - PubMed
5 days ago
- #Macrophage activation
- #Ankylosing spondylitis
- #Gut microbiota
- HLA-B27-associated gut microbiota and amino acid perturbations contribute to ankylosing spondylitis (AS) pathogenesis.
- Study involved 88 participants, including HLA-B27-positive AS patients and healthy controls, revealing microbial and metabolic shifts.
- Key disrupted pathways in AS: tryptophan metabolism, cysteine metabolism, and pyruvate-centered biosynthesis of branched-chain amino acids.
- Fecal microbiota transplantation (FMT) in mice replicated AS features, including M1 macrophage polarization and bone loss.
- Cinnabarinic acid identified as a microbial metabolite suppressing M1 macrophage polarization via the AhR pathway.
- Findings suggest microbial-metabolic pathways as potential therapeutic targets for AS.