An Update on Bile Acid-Regulated Signalling in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease - PubMed
a day ago
- #bile-acid-signaling
- #lipid-metabolism
- #MASLD
- Bile acids (BAs) play a key role in the pathogenesis of Metabolic dysfunction-associated steatotic liver disease (MASLD).
- BA-regulated signaling involves nuclear receptors (FXR, VDR, PXR) and membrane-bound receptors (TGR5, S1PR2), influencing lipid homeostasis.
- FXR agonists like obeticholic acid (OCA), cilofexor, and tropifexor show promise in clinical trials for MASLD treatment.
- Natural compounds such as hyperoside, kaempferol, and salidroside exhibit FXR-modulating properties, offering potential for new therapies.
- Further research into BA signaling mechanisms could lead to novel and effective treatments for MASLD.