GPR146 in adipose tissue drives adipose-liver crosstalk and promotes hepatic steatosis in mice - PubMed
3 hours ago
- #hepatic steatosis
- #adipose-liver crosstalk
- #GPR146
- GPR146 in adipose tissue regulates adipose-liver crosstalk and promotes hepatic steatosis in mice.
- Human genetic analyses link GPR146 to markers of liver injury and inflammation.
- Constitutive and acute GPR146 depletion in mice protects against diet-induced obesity and hepatic steatosis.
- Adipose-specific GPR146 deletion reduces hepatic lipid accumulation by limiting free fatty acid (FFA) influx.
- GPR146 promotes adipogenesis in preadipocytes via Gαq-PKC-AKT signaling and enhances lipolysis in mature adipocytes through ERK activation.
- GPR146 increases FFA delivery to the liver, promoting triglyceride accumulation.
- GPR146 is identified as a potential therapeutic target for metabolic dysfunction-associated steatotic liver disease (MASLD).