IL-3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury - PubMed
4 hours ago
- #IL-3
- #Microglia
- #Neuroinflammation
- IL-3 levels rise in cerebrospinal fluid but not blood in headache and TBI patients.
- Exogenous IL-3 reduces neuroinflammation and improves recovery in rat TBI models.
- IL-3 targets Peroxiredoxin-1 (PRDX1) in microglia to modulate polarization.
- PRDX1 knockdown abolishes IL-3's protective effects in TBI rats.
- IL-3 acts via IL-3R to recruit PRDX1, modulating microglia to inhibit neuroinflammation.
- IL-3 may be a novel therapeutic strategy for traumatic brain injury.