Bidirectional Regulation between Metabolic Dysfunction-associated Steatotic Liver Disease and Sarcopenia via Liver-muscle Crosstalk - PubMed
a day ago
- #Liver-muscle crosstalk
- #Sarcopenia
- #MASLD
- MASLD and sarcopenia frequently coexist, but their causal relationship and mechanisms are unclear.
- Mendelian randomization showed that lower muscle mass and function increase MASLD risk.
- MASLD in mice led to muscle mass loss, reduced strength, and lipid deposition in muscles.
- Muscle atrophy worsened hepatic steatosis, inflammation, and fibrosis in MASLD mice.
- Transcriptional profiling revealed impaired hepatic metabolic homeostasis in sarcopenia and muscle dysfunction in MASLD.
- C-C motif chemokine ligand 2 (a myokine) drives MASLD, and adrenomedullin (a hepatokine) triggers sarcopenia.
- A bidirectional causal relationship between MASLD and sarcopenia may exist, mediated by specific molecular mediators.