Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood - PubMed
7 days ago
- #HLA
- #Type 1 Diabetes
- #T Cell Receptor
- The study identifies a T cell receptor (TCR) repertoire signature associated with type 1 diabetes (T1D) from human peripheral blood.
- HLA risk alleles show higher restriction of TCR repertoires in individuals with T1D.
- Deep learning was used to identify T1D-associated TCR subsequence motifs, also found in pancreas-draining lymph nodes of T1D individuals.
- The findings offer potential for TCR-based diagnostics and therapeutics in T1D.
- The study involved sequencing TCRβ chains from 2250 HLA-typed participants, including T1D patients and healthy controls.