Parathyroid Hormone Contributes to Pulmonary Hypertension in Hypoxic Conditions - PubMed
3 hours ago
- #Parathyroid Hormone
- #Hypoxia
- #Pulmonary Hypertension
- Pulmonary hypertension (PH) is characterized by increased pulmonary artery pressure and can lead to right heart failure.
- Parathyroid hormone (PTH) plays a crucial role in calcium homeostasis and affects cardiovascular prognosis.
- Serum PTH levels were measured in PH patients, showing association with mean pulmonary artery pressure and pulmonary vascular resistance.
- PTH treatment worsened right ventricular hypertrophy and pressure in hypoxia-induced PH animal models.
- Parathyroidectomy reduced PTH levels, attenuating right ventricular hypertrophy and pulmonary vascular remodeling in rats.
- Hypoxia-inducible factor-1 alpha (HIF1α) promoted the PTH receptor (PTH1R) in pulmonary artery smooth muscle cells.
- Knockdown of PTH1R in lungs improved PH in animal models.
- PTH increased proliferation and migration of pulmonary artery smooth muscle cells via PTH1R-β-arrestin-ERK signaling.
- PTH/PTH1R signaling is implicated in PH development, suggesting PTH1R as a potential therapeutic target.