Novel insights into autoimmune gastritis: clinical profile and gastric neoplastic risk from an international multicentre study - PubMed
3 days ago
- #gastric adenocarcinoma
- #neuroendocrine tumours
- #autoimmune gastritis
- Autoimmune gastritis (AIG) features and gastric neoplastic risks were studied in an international multicentre study.
- The study included 1240 patients with histologically confirmed AIG from Europe, Türkiye, Latin America, the USA, and Japan.
- Clinical presentations varied by region: macrocytic anaemia was common in Europe, microcytic anaemia in Türkiye and Latin America, and autoimmune comorbidities were most frequent in Latin America.
- Gastric adenocarcinoma occurred in 2.9% of patients, while type 1 gastric neuroendocrine tumours (NETs) occurred in 10.6%.
- No incident adenocarcinomas were reported in Latin America or Japan cohorts.
- Risk factors for adenocarcinoma included age >65 years, intestinal metaplasia, high gastrin-17 levels, and prior PPI use.
- Risk factors for NETs included prior PPI use, smoking, intestinal metaplasia, and high gastrin-17 levels, while H. pylori eradication was protective.
- The study highlights regional differences in AIG presentation and neoplastic risks, suggesting the need for region-specific follow-up strategies.