Development and Validation of a Prognostic Nomogram for Post-Transcatheter Aortic Valve Replacement Heart Failure Hospitalization in Patients With Concurrent Symptomatic Aortic Stenosis and Heart Fail
12 hours ago
- #symptomatic aortic stenosis
- #predictive modeling
- #heart failure with preserved ejection fraction
- Development of a prognostic nomogram for heart failure hospitalization post-TAVR in patients with symptomatic aortic stenosis and HFpEF.
- Multicenter study involving 321 patients with severe aortic stenosis and HFpEF who underwent TAVR between 2017-2024.
- Utilized various predictive modeling techniques including random forest, XGBoost, and Cox regression analysis.
- Identified 6 independent predictors using Boruta algorithm and LASSO regression.
- Cox regression-based nomogram showed superior performance with AUC values of 0.824 at 12 months and 0.818 at 20 months.
- Nomogram outperformed European System for Cardiac Operative Risk Evaluation in discrimination and reclassification analyses.
- Interactive web-based clinical decision support tool developed for point-of-care implementation.
- Nomogram incorporates metabolic biomarkers and exhibits high predictive accuracy for HF hospitalization.