Percutaneous Coronary Intervention in Frail Patients Undergoing Transcatheter Aortic Valve Replacement: A NOTION-3 Substudy - PubMed
4 hours ago
- #frailty
- #PCI in TAVR
- #bleeding risk
- PCI in addition to TAVR significantly reduced MACE (15% vs 33%), all-cause mortality, MI, and urgent revascularization in nonfrail patients over a median follow-up of 2 years.
- For frail patients, PCI did not show any benefit in reducing MACE, mortality, MI, or urgent revascularization compared to conservative treatment.
- Frail patients undergoing PCI experienced more bleeding events (HR: 2.51) without clinical improvement, highlighting increased risk without efficacy.
- The study used a post hoc calculated frailty score based on baseline limitations, function, and quality of life, with 32% of patients classified as frail.
- Findings suggest that PCI is beneficial for nonfrail TAVR patients with CAD but may be harmful for frail patients due to higher bleeding risks.