Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders - PubMed
a day ago
- #Alzheimer's disease
- #genetic correlation
- #psychiatric disorders
- Neuropsychiatric symptoms (NPSs) occur in up to 85% of Alzheimer's disease (AD) cases.
- Genetic correlation analyses were conducted between AD and major psychiatric disorders (depression, schizophrenia, bipolar disorder, anxiety) using GWAS summary statistics.
- Shared genetic loci identified: TMEM106B (rs3173615) between AD and depression/anxiety, ACE (rs4292) between AD/schizophrenia, and ERC2 (rs17288728; rs815460) between AD/anxiety.
- These findings provide insights into shared molecular pathways and potential therapeutic targets for AD and psychiatric disorders.